Should a malalignment be the cause of the metallosis, then it should be corrected within the revision surgery. In cases with a damaged component, a partial/complete prosthesis exchange leads to the best results. A thorough debridement as well as a (sub)total synovectomy should be always performed. The purpose of this study was to evaluate calprotectin for the diagnosis of PJI in cases that preoperatively demonstrate moderate to severe periprosthetic osteolysis or implant. A systematic diagnostic approach is necessary for the timely and correct diagnosis. Concerns have already been raised in cases with metallosis and severe periprosthetic osteolysis because wear-induced inflammation may yield false positive results. Metallosis after knee arthroplasty is a rare and perhaps underestimated or under published complication. FindLaw / Learn About The Law / Accidents and Injuries / Product Liability / Cobalt Toxicity and Other Metal Hip Replacement Side Effects Cobalt Toxicity and Other Metal Hip Replacement Side Effects By FindLaw Staff Legally reviewed by Garrett Monteagudo, Esq. Complete prosthesis exchange was the most common one showing no complications in 89.4% of the cases.

Depending on the particular cause various surgical procedures have been performed. The diagnosis was confirmed by histopathological analyses and macroscopic evaluation during surgery. Complete blood cell count, serum chemistry, erythrocyte sedimentation rate or C-reactive protein serum values were not indicative to diagnose metallosis. The most common reason was the failure of a metal-backed patellar component in 40%, followed by implant/structural- and PE failure (wear/dislocation) in 27% and 18% of the cases, respectively. The time period between the primary implantation and metallosis emergence ranged between 6 weeks and 26 years. 29 studies reported on metallosis after TKA, 8 after UKA, and one study after both procedures. All publications were analyzed regarding publication year, level of evidence, number of knees/patients treated, type of prosthesis, metallosis cause, time period between primary implantation and metallosis emergence, laboratory examination, treatment, complications and follow up.Ī total of 38 studies reporting on a total of 97 knees were identified. Search terms were 'metallosis' in combination with 'knee', 'knee prosthesis', 'knee arthroplasty' and 'knee replacement', respectively. The aim of the present work was to review the current knowledge about the reasons and the diagnostic as well as therapeutic management of metallosis after knee arthroplasty.Ī literature search was performed through PubMed until April 2019. Although metallosis is a well-known complication after total hip arthroplasty, little is known about this phenomenon after total (TKA) or unicompartmental knee arthroplasty (UKA).

Hip replacement metallosis